Protein Modification Reagents
Cayman Chemical AzIdo-dPEG7-amIn 10mg
A heterobifunctional PEGylated linker; contains a reactive NH2 end group, as well as an azide functional group for use in click chemistry reactions; has been used as a linker in the synthesis of bivalent mTOR inhibitors
Medchemexpress LLC Biotin-PEG11-Mal | 1646619-56-8 | MFCD00017409 | 98.1% | C41H71N5O16S | 10MG
Biotin-PEG11-Mal is a bifunctional PEGylated linker that combines a biotin affinity tag with a maleimide reactive group for conjugation to thiol-containing biomolecules and for use in PROTAC synthesis. The PEG11 spacer provides flexibility and improved aqueous compatibility, enabling effective labeling, capture, or linkage in biochemical workflows.
- Biotin tag enables affinity purification and detection.
- Maleimide group reacts selectively with sulfhydryl (thiol) groups.
- PEG11 spacer improves solubility and reduces steric hindrance.
- High purity supports reproducible conjugation chemistry.
- Supplied as an oil in multiple pack sizes for experimental flexibility.
- Stable when stored under nitrogen at -20°C.
Medchemexpress LLC Fmoc-NH-PEG11-CH2CH2COOH | 3076038-46-2 | 98.5% | 100 MG
Fmoc-NH-PEG11-CH2CH2COOH is a PEG-based PROTAC linker. It is primarily used in the synthesis of PROTACs, which are molecules designed to degrade target proteins by leveraging the intracellular ubiquitin-proteasome system. This product is intended for research use only.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Exploits the intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
- For research use only
Medchemexpress LLC Acid-C2-PEG4-C2-NHS ester | 1343476-41-4 | 98.0% | 50 MG
Acid-C2-PEG4-C2-NHS ester is a PEG-based PROTAC linker. It is utilized in the synthesis of PROTACs, which consist of two distinct ligands connected by a linker. One ligand targets an E3 ubiquitin ligase, and the other targets a specific protein. These PROTACs leverage the intracellular ubiquitin-proteasome system to facilitate the selective degradation of target proteins.
- Molecular weight: 435.42
- Molecular formula: C18H29NO11
- Appears as a colorless to light yellow liquid
- Density: 1.30±0.1 g/cm3
- Soluble in DMSO at 100 mg/mL
- For research use only
- Available documentation includes data sheet, SDS, COA, HNMR, and MS
Creative Pegworks 4-Arm PEG-MAL, MW 5k - 10g
4-Arm PEG-MAL is a multiarmed PEG derivative with maleimide at each terminal of the four arms connected to one pentaerythritol core. Maleimide selectively reacts with free thiol, SH, sulfhydryl, or mercapto group via Michael addition to form a stable thioether bond. PEG-MAL useful for site specific protein and peptide modification. Hydroquinone MEHQ at ~ 200 ppm may be present as inhibitors to prevent self polymerization and partial crosslinking. MEHQ may be removed per customer request.
Medchemexpress LLC (S,R,S)-AHPC-PEG5-Boc | 2923734-82-9 | 95.3% | C40H62N4O11S | 10MG
(S,R,S)-AHPC-PEG5-Boc is an E3 ligase ligand-linker conjugate that couples an (S,R,S)-AHPC-based VHL ligand to a PEG5 linker with a Boc protecting group. Supplied as a solid research reagent, it is intended for use as the ligand-linker component in PROTACs such as Cdc20-targeting degraders.
- Incorporates the (S,R,S)-AHPC VHL ligand
- Contains a PEG5 linker with Boc protection
- Provided as a solid, light yellow to yellow material
- Molecular formula: C40H62N4O11S
- Molecular weight: 807.01 g·mol⁻¹
- Reported purity: 95.3%
- Storage: -20 °C under nitrogen; in solvent -80 °C (6 months) or -20 °C (1 month)
- Available in milligram to gram sizes for research use
Medchemexpress LLC Dspe-peg4-dbco | 2112738-14-2 | MFCD30828684 | 95.0% | C71H116N3O15P | 10MG
DSPE-PEG4-DBCO is a lipid-polyethylene glycol conjugate bearing a dibenzocyclooctyne (DBCO) reactive group used for copper-free click chemistry and bioconjugation. It enables strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-functionalized partners, facilitating liposome functionalization, surface modification, and linker assembly in aqueous and physiological conditions.
- Provides a DBCO reactive handle for copper-free SPAAC.
- Contains a PEG4 spacer for improved solubility and reduced steric hindrance.
- Includes a lipid anchor for incorporation into lipid bilayers and liposomes.
- Suitable for bioconjugation under physiological conditions.
- High purity for consistent reaction performance.